Nutrição e Envelhecimento – Artigo 15

Serum Tocopherol Levels and Vitamin E Intake are Associated with Lung Function in the Normative Aging Study Abstract Background and Aims—The results of studies assessing relationships between vitamin E intake and status and lung function are conflicting. This study aimed to evaluate the effect of vitamin E intake and serum levels of tocopherol isoforms on lung function in a cross-sectional sample of 580 men from the Normative Aging ...

Nutrição e Envelhecimento – Artigo 14

Regulation of metabolic health and aging by nutrient-sensitive signaling pathways Abstract All organisms need to be capable of adapting to changes in the availability and composition of nutrients. Over 75 years ago, researchers discovered that a calorie restricted (CR) diet could significantly extend the lifespan of rats, and since then a CR diet has been shown to increase lifespan and healthspan in model organisms ranging from yeast to ...

Nutrição e Envelhecimento – Artigo 13

Proteostasis, oxidative stress and aging ABSTRACT The production of reactive species is an inevitable by-product of metabolism and thus, life itself. Since reactive species are able to damage cellular structures, especially proteins, as the most abundant macromolecule of mammalian cells, systems are necessary which regulate and preserve a functional cellular protein pool, in a process termed “proteostasis”. Not only the mammalian ...

Nutrição e Envelhecimento – Artigo 12

Nutritional Considerations for Healthy Aging and Reduction in Age-Related Chronic Disease  ABSTRACT A projected doubling in the global population of people aged $60 y by the year 2050 has major health and economic implications, especially in developing regions. Burdens of unhealthy aging associated with chronic noncommunicable and other age-related diseases may be largely preventable with lifestyle modification, including diet. However, ...

Nutrição e Envelhecimento – Artigo 11

Nutrition and other Lifestyle Influences on Arterial Aging Abstract As our world’s population ages, cardiovascular diseases (CVD) will become an increasingly urgent public health problem. A key antecedent to clinical CVD and many other chronic disorders of aging is age-related arterial dysfunction, characterized by increased arterial stiffness and impaired arterial endothelial function. Accumulating evidence demonstrates that diet and ...

Nutrição e Envelhecimento – Artigo 10

Nutrition and lifestyle in healthy aging: the telomerase challenge Abstract: Nutrition and lifestyle, known to modulate aging process and age‐related diseases, might also affect telomerase activity. Short and dysfunctional telomeres rather than average telomere length are associated with longevity in animal models, and their rescue by telomerase maybe sufficient to restore cell and organismal viability. Improving telomerase activation ...

Nutrição e Envelhecimento – Artigo 9

Nutrients, Microglia Aging, and Brain Aging As the life expectancy continues to increase, the cognitive decline associated with Alzheimer’s disease (AD) becomes a big major issue in the world. After cellular activation upon systemic inflammation, microglia, the resident immune cells in the brain, start to release proinflammatory mediators to trigger neuroinflammation. We have found that chronic systemic inflammatory challenges induce ...

Nutrição e Envelhecimento – Artigo 8

MITOCHONDRIAL FUNCTION IN HYPOXIC ISCHEMIC INJURY AND INFLUENCE OF AGING Abstract Mitochondria are a major target in hypoxic/ischemic injury. Mitochondrial impairment increases with age leading to dysregulation of molecular pathways linked to mitochondria. The perturbation of mitochondrial homeostasis and cellular energetics worsens outcome following hypoxicischemic insults in elderly individuals. In response to acute injury conditions, ...