BEYOND THE PALEOLITHIC PRESCRIPTION: INCORPORATING DIVERSITY AND FLEXIBILITY IN THE STUDY OF HUMAN DIET EVOLUTION
Abstract
Evolutionary paradigms of human health and nutrition center on the evolutionary discordance or “mismatch” model whereby human bodies, reflecting adaptations established in the Paleolithic era, are ill-suited to modern industrialized diets resulting in rapidly increasing rates of chronic
metabolic disease. Whereas ...
White blood cell inflammatory markers are associated with depressive symptoms in a longitudinal study of urban adults
INTRODUCTION
Unipolar depression is a chronic condition1,2 accounting for a major part of the health care system,3 with a lifetime prevalence among American adults of ~ 12% in men and ~ 21% in women.3 Depression and elevated depressive symptoms in general were linked to altered immunity.4–37 Several studies included in ...
Vitamin D supplementation to prevent depression and poor physical function in older adults: Study protocol of the D-Vitaal study, a randomized placebo-controlled clinical trial
Background: Depressive symptoms and decreased physical functioning are interrelated conditions and common in older persons, causing significant individual and societal burden. Evidence suggests that vitamin D supplementation may be beneficial for both mental and ...
Vitamin D levels and perinatal depressive symptoms in women at risk: a secondary analysis of the mothers, omega-3, and mental health study
Background: Vitamin D insufficiency may be associated with depressive symptoms in non-pregnant adults. We performed this study to evaluate whether low maternal vitamin D levels are associated with depressive symptoms in pregnancy.
Methods: This study was a secondary analysis of a randomized trial ...
Vitamin D Deficiency and Depressive Symptomatology in Psychiatric Patients
Hospitalized with a Current Depressive Episode: A Factor Analytic Study
Background
Low vitamin D levels have been associated with depressive symptoms in population-based studies and non-clinical samples as well as with clinical depression. This study aimed to examine the association of vitamin D levels with the severity and dimensions of depressive
symptoms in ...
The Effects of High-fat-diet Combined with Chronic Unpredictable Mild Stress on Depression-like Behavior and Leptin/LepRb in Male Rats
Obesity is a condition characterized by massive adipose tissue accumulation, which is usually caused by complicated
genetic and environmental factors1–3. Obesity is associated with many health problems including metabolic
syndrome, cardiovascular diseases and psychiatric disorders4–7. Depression is a ...
Suppression of Neuroinflammatory and Apoptotic Signaling Cascade by curcumin Alone and in Combination with Piperine in Rat Model of Olfactory
Bulbectomy Induced Depression
Objectives: Bilateral destruction of the olfactory bulbs is known to cause behavioral changes analogous to symptoms of depression. Curcumin, a traditional Indian spice is currently being investigated in different psychiatric problems including depression. Dietary ...
Oxidative stress predicts depressive symptom changes with omega-3
fatty acid treatment in coronary artery disease patients
Background: Antidepressant efficacy of omega-3 polyunsaturated fatty acid (n-3 PUFA) treatment in coronary artery disease (CAD) patients remains unpredictable. N-3 PUFA can mitigate oxidative stress, which is common in CAD and may contribute to depressive symptoms. This study investigated whether greater pre-treatment ...
