Nutrição e Hipocloridria – Artigo 9
Hunger and microbiology: is a low gastric acid-induced bacterial overgrowth in the small intestine a contributor to malnutrition in developing countries?
Summary
Underproduction of hydrochloric acid into the stomach is frequently encountered in subjects from developing countries. We explore the hypothesis that hypochlorhydria compromises the gastric barrier and favours bacterial overgrowth in the proximal parts of the small intestine where nutrient absorption takes place. Food calories are thus deviated into bacterial metabolism. In addition to an adequate caloric supply, correcting ...
Nutrição e Hipocloridria – Artigo 8
Novel concepts in the pathophysiology and treatment of functional dyspepsia
ABSTRACT
Emerging data increasingly point towards the duodenum as a key region underlying the pathophysiology of functional dyspepsia (FD), one of the most prevalent functional GI disorders. The duodenum plays a major role in the control and coordination of gastroduodenal function. Impaired duodenal mucosal integrity and low-grade inflammation have been associated with altered neuronal signalling and systemic immune activation, and these alterations may ultimately lead to dyspeptic symptoms. Likely luminal ...
Nutrição e Hipocloridria – Artigo 7
The Potential Role of Hypochlorhydria in the Development of Duodenal Dysbiosis: A Preliminary Report
In recent years, the role of gastric and duodenal microbiota has acquired increasing importance in the homeostasis of the host, although, to date, most evidence concern the faecal microbiota. Indeed, the gastric, and duodenal microbiota are challenging to study, due to gastric acid, bile, digestive enzymes, and rapid transit time. Specifically, the gastric acid environment may influence their bacterial composition since the acid barrier protects against orally ingested microorganisms and ...
Nutrição e Hipocloridria – Artigo 6
Overview of Helicobacter pylori Infection: Clinical Features, Treatment, and Nutritional Aspects
Abstract: Helicobacter pylori (H. pylori) is a 0.5–1 m wide, 2–4 m long, short helical, S-shaped Gramnegative
microorganism. It is mostly found in the pyloric region of the stomach and causes chronic gastric infection. It is estimated that these bacteria infect more than half of the world’s population. The mode of transmission and infection of H. pylori is still not known exactly, but the faecal–oral and oral–oral routes via water or food consumption are thought to be a very common ...
Nutrição e Hipocloridria – Artigo 5
Nutritional Assessment of the Symptomatic Patient on a Plant-Based Diet: Seven Key Questions
Abstract: Plant-based diets, both vegan and vegetarian, which emphasize grains, vegetables, fruits, legumes, nuts, and seeds are increasingly popular for health as well as financial, ethical, and religious reasons. The medical literature clearly demonstrates that whole food plant-based diets can be both nutritionally sufficient and medically beneficial. However, any person on an intentionally restrictive, but poorly-designed diet may predispose themselves to clinically-relevant nutritional defici...
Nutrição e Hipocloridria – Artigo 3
The Phylogeny and Biological Function of Gastric Juice—Microbiological Consequences of Removing Gastric Acid
Abstract:
Gastric juice is a unique combination of hydrochloric acid (HCl), lipase, and pepsin. Acidic gastric juice is found in all vertebrates, and its main function is to inactivate microorganisms. The phylogenetic preservation of this energy-consuming and, at times, hazardous function (acid-related diseases) reflects its biological importance. Proton pump inhibitors (PPIs) are one of the most widely used drugs in the world. Due to the reduced prevalence of Helicobacter pylori ...
Nutrição e Hipocloridria – Artigo 2
Nutritional Interventions for Gastroesophageal Reflux, Irritable Bowel Syndrome, and Hypochlorhydria: A Case
Report
Abstract
Chronic gastrointestinal (GI) complaints are often treated with proton pump inhibitors (PPIs), antibiotics, and other medications that offer temporary relief of acute symptoms. Although these drugs are prescribed to provide promising results, new research indicates the drug treatments often mask unresolved physiological problems and cause further complications. Complex GI cases require a comprehensive assessment and a multifaceted approach. This case reports on the ...
Nutrição e Hipocloridria – Artigo 1
Meal-Time Supplementation with Betaine HCl for Functional Hypochlorhydria: What is the Evidence?
Abstract
It is well established that the inadequate intake of key nutrients can lead to nutrient deficiency-related phenomena. However, even when the intake of nutrients is sufficient, the inadequate digestion and/or absorption of macronutrients, micronutrients or other therapeutic compounds from the diet (i.e., phytonutrients) can result in similar clinical consequences. These consequences include classic GI-related symptoms related to malabsorption, as well as a broad range of clinical and ...
