Nutrição e Saúde Mitocondrial – Artigo 14
Medium Chain Triglycerides enhances exercise endurance through the increased
mitochondrial biogenesis and metabolism
Abstract
Medium Chain Triglycerides (MCT) is a dietary supplement and usually used along with medications for treating food absorption disorders including diarrhea, steatorrhea and liver
disease. It has been shown that MCT plays a role in lowering weight, and decreasing metabolic
syndrome, abdominal obesity and inflammation. However, it is still unknown whether MCT ...
Nutrição e Saúde Mitocondrial – Artigo 13
Leucine Supplementation Differently Modulates Branched-Chain Amino Acid Catabolism, Mitochondrial Function and Metabolic Profiles at the Different Stage of Insulin Resistance in Rats on High-Fat Diet
Abstract: The available findings concerning the association between branched-chain amino acids
(BCAAs)—particularly leucine—and insulin resistance are conflicting. BCAAs have been proposed
to elicit different or even opposite effects, depending on the prevalence of catabolic and ...
Nutrição e Saúde Mitocondrial – Artigo 12
Guarana (Paullinia cupana) Stimulates Mitochondrial Biogenesis in Mice Fed High-Fat Diet
Abstract: The aim of this study was to evaluate the effects of guarana on mitochondrial biogenesis
in a high-fat diet (HFD)-fed mice. C57BL6J mice were divided in two groups: high-fat diet HFD
and high-fat diet + guarana (HFD-GUA). Both groups received HFD and water ad libitum and
the HFD-GUA group also received a daily gavage of guarana (1 g/kg weight). Body weight and
food intake was measured ...
Nutrição e Saúde Mitocondrial – Artigo 11
Fructose-Rich Diet Affects Mitochondrial DNA Damage and Repair in Rats
Abstract: Evidence indicates that many forms of fructose-induced metabolic disturbance are
associated with oxidative stress and mitochondrial dysfunction. Mitochondria are prominent targets of oxidative damage; however, it is not clear whether mitochondrial DNA (mtDNA) damage and/or its lack of repair are events involved in metabolic disease resulting from a fructose-rich diet. In the present study, we evaluated the ...
Nutrição e Saúde Mitocondrial – Artigo 10
Effects of epigallocatechin-3-gallate on thermogenesis and mitochondrial biogenesis in brown adipose tissues of diet-induced obese mice
ABSTRACT
Background: Epigallocatechin-3-gallate (EGCG) is the major polyphenol in green tea and has been considered a natural agent that can help to reduce the risk of obesity.
Objective: The aim of this study was to investigate the effects of EGCG on thermogenesis and
mitochondrial biogenesis in brown adipose tissue (BAT) of diet-induced obese mice.
...
Nutrição e Saúde Mitocondrial – Artigo 9
Effects of Eicosapentaenoic Acid and Docosahexaenoic Acid on Mitochondrial DNA Replication and PGC-1α Gene Expression in C2C12 Muscle Cells
ABSTRACT: Mitochondrial biogenesis is a complex process requiring coordinated expression of nuclear and mitochondrial genomes. The peroxisome proliferator-activated receptor gamma co-activator 1-alpha (PGC-1α) is a key regulator of mitochondrial biogenesis, and it controls mitochondrial DNA (mtDNA) replication within diverse tissues, including ...
Nutrição e Saúde Mitocondrial – Artigo 8
Effect of Dietary Bioactive Compounds on Mitochondrial and Metabolic Flexibility
Abstract: Metabolic flexibility is the capacity of an organism to adequately respond to changes in the environment, such as nutritional input, energetic demand, etc. An important player in the capacity of adaptation through different stages of metabolic demands is the mitochondrion. In this context, mitochondrial dysfunction has been attributed to be the onset and center of many chronic diseases, which are ...
Nutrição e Saúde Mitocondrial – Artigo 7
Distinct roles for REV-ERBα and REV-ERBβ in oxidative capacity and mitochondrial
biogenesis in skeletal muscle
Abstract
The nuclear receptors REV-ERBα and REV-ERBβ have been demonstrated to be core members
of the circadian clock and participate in the regulation of a diverse set of metabolic functions.
Due to their overlapping tissue expression patterns and gene expression profiles, REV-ERBβ is thought to be redundant to REV-ERBα. Recent work has highlighted REVERBα' s role in ...
