Regulation of glucagon-like peptide-1 sensitivity by gut microbiota dysbiosis It has been reported that L-arginine is a GLP-1 secretagogue, and that improvement of glucose tolerance by oral L-arginine administration is dependent on GLP-1R signaling5. Interestingly, in HFD fed mice with severe GLP-1 resistance, glucose-induced insulin secretion was increased by acute and chronic treatment with L-arginine, a substrate of nNOS, suggesting improved GLP-1 sensitivity. These findings...
