Nutrição e HIV – Artigo 6
Genome-Wide Analyses Reveal Gene Influence on HIV Disease Progression and HIV-1C Acquisition in Southern Africa
Abstract
Sub-Saharan Africans infected with HIV-1C make up the largest AIDS patient population in the world and exhibit large heterogeneity in disease progression before initiating antiretroviral therapy. To identify host variants associated with HIV disease progression, we performed genome-wide association studies on a total of 556 treatment-naive HIV-infected individuals in Botswana. We characterized the pattern of HIV disease progression using a novel functional princi...
Nutrição e HIV – Artigo 5
Food elimination, food substitution, and nutrient supplementation among ARVexposed HIV-positive persons in southern Ghana
Abstract
Background: Optimal nutrition is a determinant of health in all persons. In persons living with HIV (PLHIV), nutrition is particularly important. Various factors, including dietary practices, play a role in guaranteeing nutritional health.
Objectives: We investigated multiple non-prescription drugs use among HIV-positive persons receiving antiretroviral therapy (ART) from four treatment centers in southern Ghana. This paper, however, focuses on nutrient ...
Nutrição e HIV – Artigo 4
Effects of Vitamin D Supplementation on Bone Mineral Density and Bone Markers in HIV-infected Youth
Abstract
Background—Low bone mineral density (BMD) is a significant co-morbidity in HIV. However, studies evaluating vitamin D supplementation on bone health in this population are limited. This study investigates changes in bone health parameters after 12 months of supplementation in HIVinfected youth with vitamin D insufficiency.
Methods—This is a randomized, active-control, double-blind trial investigating changes in bone parameters with 3 different vitamin D3 doses [18,000 ...
Nutrição e HIV – Artigo 3
Effects of Amprenavir on HIV-1 Maturation, Production and Infectivity Following Drug
Withdrawal in Chronically-Infected Monocytes/Macrophages
Abstract: A paucity of information is available on the activity of protease inhibitors (PI) in chronically-infected monocyte-derived macrophages (MDM) and on the kinetics of viral-rebound after PI removal in vitro. To fill this gap, the activity of different concentrations of amprenavir (AMP) was evaluated in chronically-infected MDM by measuring p24-production every day up to 12 days after drug administration and up to seven days after drug ...
Nutrição e HIV – Artigo 2
Effect of vitamin A and vitamin C supplementation on oxidative stress in HIV and HIV-TB co-infection at Lagos University Teaching Hospital (LUTH) Nigeria.
Abstract
Background: HIV and TB infections are both associated with elevated oxidative stress parameters. Anti-oxidant supplementation may offer beneficial effects in positively modulating oxidative stress parameters in HIV and HIV-TB infected patients. We investigated the effects of vitamin A and C supplementation on oxidative stress in HIV infected and HIV-TB co-infected subjects.
Methods: 40 HIV/TB co-infected and 50 HIV mono-i...
Nutrição e HIV – Artigo 1
Bundled HIV and Hepatitis C Testing in the Emergency Department: A Randomized Controlled Trial
Introduction: An estimated 25% of the 1.2 million individuals living with human immunodeficiency virus (HIV) in the U.S. are co-infected with hepatitis C (HCV). The Centers for Disease Control and Prevention recommends HCV testing for high-risk groups. Our goal was to measure the impact of bundled HIV and HCV testing vs. HIV testing alone on test acceptance and identification of HCV and HIV.
Methods: We conducted a two-armed, randomized controlled trial on a convenience sample of 478 adult ...
Nutrição e Doença de Cron – Artigo 20
Vitamin D increases programmed death receptor-1 expression in Crohn’s disease
ABSTRACT
Background: Vitamin D modulates inflammation in Crohn’s disease (CD). Programmed death (PD)-1 receptor contributes to the maintenance of immune tolerance. Vitamin D might modulate PD-1 signalling in CD.
Aim: To investigate PD-1 expression on T cell subsets in CD patients treated with vitamin D or placebo.
Methods: We included 40 CD patients who received 1200 IU vitamin D3 for 26 weeks or placebo and eight healthy controls. Peripheral blood mononuclear cells (PBMCs) and plasma were isolated ...
Nutrição e Doença de Cron – Artigo 19
Ulcerative Colitis and Crohn’s Disease Are Associated with Decreased Serum Selenium
Concentrations and Increased Cardiovascular Risk
Abstract: The incidence of inflammatory bowel disease (IBD) and associated oxidative stress is increasing. The antioxidant mineral selenium (Se) was measured in serum samples from 106 IBD patients (53 with ulcerative colitis (UC) and 53 with Crohn’s disease (CD)) and from 30 healthy controls. Serum Se concentrations were significantly lower in UC and CD patients than in healthy controls (p < 0.001) and significantly lower in CD patients than in ...
