Nutrição e Doença Celíaca – Artigo 10
Effector and suppressor T cells in celiac disease
Abstract
Celiac disease (CD) is a T-cell mediated immune disease in which gliadin-derived peptides activate lamina propria effector CD4+ T cells. This activation leads to the release of cytokines, compatible with a Th1-like pattern, which play a crucial role in the pathogenesis of CD, controlling many aspects of the inflammatory immune response. Recent studies have shown that a novel subset of effector T cells, characterized by expression of high levels of IL-17A, termed Th17 cells, plays a pathogenic role in CD. While these ...
Nutrição e Doença Celíaca – Artigo 9
Effect of Gliadin on Permeability of Intestinal Biopsy Explants from Celiac Disease Patients and Patients with Non-Celiac Gluten Sensitivity
Abstract: Background: Intestinal exposure to gliadin leads to zonulin upregulation and consequent disassembly of intercellular tight junctions and increased intestinal permeability. We aimed to study response to gliadin exposure, in terms of barrier function and cytokine secretion, using intestinal biopsies obtained from four groups: celiac patients with active disease (ACD), celiac patients in remission (RCD), non-celiac patients with gluten sensit...
Nutrição e Doença Celíaca – Artigo 8
Dietary compliance in celiac disease
Abstract
Celiac disease is an immune-mediated disorder that causes severe architectural disturbance in the small
intestinal mucosa of genetically-predisposed individuals. Impaired absorption of multiple nutrients results
and diarrhea and weight loss develop. Evidence has accumulated that a strict gluten-free diet can result in resolution of diarrhea, weight gain and normalization of nutrient malabsorption. In addition, histopathological
changes also normalize, but this histopathological response appears to be time-dependent, sex-dependent
and ...
Nutrição e Doença Celíaca – Artigo 7
Diet and Psoriasis: Part 2. Celiac Disease and Role of a Gluten-Free Diet
Abstract
Psoriasis patients have been shown to have a higher prevalence of other autoimmune diseases including celiac disease, a condition marked by sensitivity to dietary gluten. A number of studies suggest that psoriasis and celiac disease share common genetic and inflammatory pathways. Here we review the epidemiologic association between psoriasis and celiac disease and perform a metaanalysis to determine whether psoriasis patients more frequently harbor serologic markers of celiac disease. We also examine ...
Nutrição e Doença Celíaca – Artigo 6
Deficiencia de micronutrientes y enfermedad
celíaca en pediatría
RESUMEN
La enfermedad celíaca (EC) parece estar cambiando en su clínica, desde formas diarreicas con desnutrición hasta aquellas con clínica más silente y más tardía. La enteropatía de la EC ocurre con malabsorción de macro- y micronutrientes, que incluyen Fe, Zn, Cu, folato, Ca, vitaminas E, D, B12 y B6, con mecanismos de transporte
alterados. La anemia ferropriva se ha descrito en EC como única manifestación o como la manifestación extraintestinal más frecuente. La deficiencia de Zn es frecuente ...
Nutrição e Doença Celíaca – Artigo 5
Celiac Disease and Overweight in Children: An Update
Abstract: The clinical presentation of celiac disease in children is very variable and differs with age. The prevalence of atypical presentations of celiac disease has increased over the past 2 decades. Several studies in adults and children with celiac disease indicate that obesity/overweight at disease onset is not unusual. In addition, there is a trend towards the development of overweight/obesity in celiac patients who strictly comply with a gluten-free diet. However, the pathogenesis and clinical implications of the coexistence ...
Nutrição e Doença Celíaca – Artigo 4
Bone Mineral Density at Diagnosis of Celiac Disease and after 1 Year of Gluten-Free Diet
1. Introduction
Celiac disease (CD) is a chronic immune-mediated disorder, characterized by villus atrophy of the proximal small
intestinal mucosa and malabsorption of nutrients after the ingestion of wheat gluten or related proteinsin genetically susceptible individuals expressing the HLA class II molecules DQ2 or DQ8. Prompt clinical and histologic improvement is observed following strict adherence to a gluten-free diet (GFD) [1]. Several extraintestinal manifestations, including anemia, ...
Nutrição e Doença Celíaca – Artigo 3
B vitamins related to homocysteine metabolism in adults celiac disease patients: a cross-sectional study
Abstract
Background: The only treatment for celiac disease is the gluten-free diet. Few studies have assessed the nutritional
adequacy of this diet, especially of B vitamins related to homocysteine metabolism. The aim of this study was to
assess the nutritional status and serum concentrations of B vitamins involved in homocysteine metabolism, and to
determine whether the dietary intake of these vitamins are meeting Dietary Reference Intakes in celiac patients.
Methods: A cross-...
