Nutrição e Depressão – Artigo 3
Decreased Prostaglandin D2 Levels in Major Depressive Disorder Are Associated with Depression- Like Behaviors
Abstract
Background: Prostaglandin (PG) D2 is the most abundant prostaglandin in the mammalian brain. The physiological and pharmacological actions of PGD2 in the central nervous system seem to be associated with some of the symptoms exhibited by patients with major depressive disorder. Previous studies have found that PGD2 synthase was decreased in the cerebrospinal fluid of major depressive disorder patients. We speculated that there may be a dysregulation of PGD2 levels ...
Nutrição e Depressão – Artigo 2
Complementary and Alternative Medicine Therapies for Perinatal Depression
Abstract
Complementary and Alternative Medicine (CAM) therapies are increasingly sought out by patients with psychiatric disorders. This article provides a review of the evidence for several
commonly utilized CAM therapies (i.e. omega-3 fatty acids, folate, S-adenosyl-methionine
(SAMe), St. John’s Wort, bright light therapy, exercise, massage, and acupuncture) in the
treatment of perinatal depression. A number of these treatments may be reasonable to consider for women during pregnancy or the postpartum, but ...
Nutrição e Depressão – Artigo 1
A study on the relationship between compulsive exercise, depression and anxiety
Background and aims: Exercise and physical activity are beneficial both physically and psychologically but a few individuals use exercise excessively resulting in physical and even psychological damage. There is evidence for bidirectional relationship between exercise with depression and anxiety showing that exercise can reduce anxiety and depression, whereas a lack of exercise is associated with higher levels of anxiety and depression. Methods: This study used questionnaires assessing compulsive exercise, ...
Nutrição e Disbiose – Artigo 19
Western diets, gut dysbiosis, and metabolic diseases: Are they linked?
ABSTRACT
Obesity afflicts 36.5% of the US population and 600 million individuals world-wide. Thus, it is imperative to understand the risk factors underlying metabolic disease including diet, activity level, sleep, and genetics. Another key contributory factor is the gut microbiota given its widely reported role in the development of metabolic disease. The gut microbiota, particularly its structure and function, is heavily influenced by Western style diets rich in a complex mixture of fats and high in simple ...
Nutrição e Disbiose – Artigo 18
Vitamin D Deficiency Promotes Epithelial Barrier Dysfunction and Intestinal Inflammation
Background. Vitamin D, an important modulator of the immune system, has been shown to protect mucosal
barrier homeostasis. This study investigates the effects of vitamin D deficiency on infection-induced changes in
intestinal epithelial barrier function in vitro and on Citrobacter rodentium–induced colitis in mice.
Methods. Polarized epithelial Caco2-bbe cells were grown in medium with or without vitamin D and challenged
with enterohemorrhagic Escherichia coli O157:H7. Barrier function and tight ...
Nutrição e Disbiose – Artigo 17
Understanding the Representative Gut Microbiota Dysbiosis in Metformin-Treated Type 2 Diabetes Patients Using Genome-Scale Metabolic Modeling
Dysbiosis in the gut microbiome composition may be promoted by therapeutic drugs such as metformin, the world’s most prescribed antidiabetic drug. Under metformin treatment, disturbances of the intestinal microbes lead to increased abundance of Escherichia spp., Akkermansia muciniphila, Subdoligranulum variabile and decreased abundance of Intestinibacter bartlettii. This alteration may potentially lead to adverse effects on the host ...
Nutrição e Disbiose – Artigo 16
Transglutaminases in Dysbiosis As Potential Environmental Drivers of Autoimmunity
Protein-glutamine g-glutamyltransferases (transglutaminases, Tgs) belong to the class of transferases. They catalyze the formation of an isopeptide bond between the acyl group at the end of the side chain of protein- or peptide-bound glutamine residues and the first order +-amine groups of protein- or peptide-bound lysine. The Tgs are considered to be universal protein cross-linkers, and they play an essential role in a number of human diseases. In this review, we discuss mainly the bacterial Tgs ...
Nutrição e Disbiose – Artigo 15
Suppression of gut dysbiosis reverses Western diet-induced vascular dysfunction
Battson ML, Lee DM, Jarrell DK, Hou S, Ecton KE, Weir TL, Gentile CL. Suppression of gut dysbiosis reverses Western dietinduced vascular dysfunction. Am J Physiol Endocrinol Metab 314: E468–E477, 2018. First published December 26, 2017; doi:10.1152/ ajpendo.00187.2017.—Vascular dysfunction represents a critical preclinical step in the development of cardiovascular disease. We examined the role of the gut microbiota in the development of obesityrelated vascular dysfunction. Male C57BL/6J mice were ...
